Large commercial buildings in NYC

1,059 buildings across 26 neighborhoods, from the city's own tax lot records: office, retail and industrial buildings with at least 100,000 square feet of that space in Manhattan and 50,000 elsewhere. The five largest in each neighborhood are below.

Midtown

  1. 1221 Avenue of the AmericasOffice building · 2.4M SF office · 51 floors · built 1971
  2. 1631 BroadwayOffice building · 2.2M SF office · 48 floors · built 1972
  3. 1111 Avenue of the AmericasOffice building · 2.2M SF office · 55 floors · built 2005
  4. 1250 Avenue of the AmericasCommercial condominium · 2.1M SF office · 70 floors · built 1937
  5. 270 Park AvenueOffice building · 2.1M SF office · 60 floors · built 2021
All 240 buildings in Midtown

Grand Central

  1. 51 East 42nd StreetOffice building · 1.6M SF office · 60 floors · built 2017
  2. 245 Park AvenueOffice building · 1.5M SF office · 45 floors · built 1966
  3. 150 East 42nd StreetCommercial condominium · 1.2M SF office · 42 floors · built 1955
  4. 230 Park AvenueOffice building · 1.2M SF office · 34 floors · built 1929
  5. 60 East 42nd StreetOffice building · 1.1M SF office · 55 floors · built 1929
All 59 buildings in Grand Central

Times Square

  1. 825 Eighth AvenueOffice building · 1.6M SF office · 49 floors · built 1987
  2. 1515 BroadwayOffice building · 1.4M SF office · 54 floors · built 1970
  3. 592 Seventh AvenueOffice building · 1.1M SF office · 38 floors · built 2000
  4. 640 Eighth AvenueCommercial condominium · 743K SF office · 40 floors · built 2007
  5. 1538 BroadwayCommercial condominium · 713K SF office · 42 floors · built 1989
All 17 buildings in Times Square

Hudson Yards

  1. 427 Tenth AvenueOffice building · 2.5M SF office · 58 floors · built 2019
  2. 500 West 33rd StreetCommercial condominium · 2.3M SF office · 68 floors · built 2015
  3. 527 West 34th StreetOffice building · 2.2M SF office · 66 floors · built 2018
  4. 601 West 26th StreetOffice building with commercial space · 1.8M SF office · 19 floors · built 1931
  5. 2 Manhattan WestCommercial condominium · 1.8M SF office · 60 floors · built 2020
All 25 buildings in Hudson Yards

Garment District

  1. 250 West 34th StreetOffice building · 2.3M SF office · 57 floors · built 1972
  2. 441 Seventh AvenueDepartment store building · 2.2M SF retail · 19 floors · built 1930
  3. 393 Seventh AvenueOffice building · 1.1M SF office · 26 floors · built 1926
  4. 1411 BroadwayOffice building · 1.0M SF office · 42 floors · built 1969
  5. 100 West 33rd StreetOffice building with commercial space · 913K SF office · 12 floors · built 2001
All 90 buildings in Garment District

Midtown South

  1. 338 Fifth AvenueOffice building · 2.7M SF office · 102 floors · built 1931
  2. 380 Park Avenue SouthOffice building · 1.0M SF office · 34 floors · built 1928
  3. 2 Park AvenueOffice building · 797K SF office · 25 floors · built 1928
  4. 63 Madison AvenueOffice building with commercial space · 601K SF office · 15 floors · built 1962
  5. 1240 BroadwayOffice building · 571K SF office · 39 floors · built 1969
All 81 buildings in Midtown South

Flatiron

  1. 1 Madison AvenueOffice building · 1.2M SF office · 26 floors · built 1932
  2. 1097 BroadwayOffice building with commercial space · 586K SF office · 15 floors · built 1909
  3. 35 Madison AvenueOffice building · 520K SF office · 43 floors · built 1971
  4. 354 Park Avenue SouthOffice building · 439K SF office · 21 floors · built 1913
  5. 40 West 23rd StreetOffice building with commercial space · 360K SF office · 12 floors · built 1911
All 38 buildings in Flatiron

Union Square

  1. 114 Fifth AvenueOffice building with commercial space · 329K SF office · 18 floors · built 1909
  2. 230 Park Avenue SouthOffice building with commercial space · 311K SF office · 13 floors · built 1900
  3. 35 Irving PlaceOffice building · 288K SF office · 12 floors · built 1909
  4. 215 Park Avenue SouthOffice building · 275K SF office · 20 floors · built 1910
  5. 44 East 14th StreetRetail building · 263K SF retail · 7 floors · built 1971
All 27 buildings in Union Square

Chelsea

  1. 518 West 26th StreetOffice building with commercial space · 196K SF office · 10 floors · built 1910
  2. 555 West 18th StreetOffice building · 195K SF office · 10 floors · built 2007
  3. 322 Eighth AvenueOffice building · 166K SF office · 21 floors · built 1925
  4. 239 West 28th StreetOffice building with commercial space · 138K SF office · 12 floors · built 1917
  5. 524 West 23rd StreetSelf-storage building · 128K SF industrial and storage · 10 floors · built 1931
All 10 buildings in Chelsea

Meatpacking

  1. 111 Eighth AvenueOffice building with commercial space · 2.2M SF office · 17 floors · built 1931
  2. 75 Ninth AvenueOffice building with commercial space · 987K SF office · 8 floors · built 1905
  3. 85 Tenth AvenueOffice building with commercial space · 460K SF office · 11 floors · built 1914
  4. 25 Eleventh AvenueOffice building with commercial space · 326K SF office · 5 floors · built 1900
  5. 99 Tenth AvenueIndustrial condominium · 189K SF industrial and storage · 11 floors · built 1917
All 13 buildings in Meatpacking

SoHo

  1. 16 Walker StreetOffice building · 1.1M SF office · 26 floors · built 1914
  2. 310 Hudson StreetOffice building with commercial space · 925K SF office · 19 floors · built 2021
  3. 431 Canal StreetOffice building with commercial space · 894K SF office · 17 floors · built 1930
  4. 161 Avenue of the AmericasOffice building with commercial space · 577K SF office · 13 floors · built 1926
  5. 101 Avenue of the AmericasOffice building · 400K SF office · 25 floors · built 1990
All 36 buildings in SoHo

NoHo

  1. 726 BroadwayOffice building with commercial space · 302K SF office · 10 floors · built 1919
  2. 740 BroadwayOffice building with commercial space · 294K SF office · 12 floors · built 1910
  3. 51 Astor PlaceOffice building with commercial space · 288K SF office · 14 floors · built 2012
  4. 592 BroadwayOffice building with commercial space · 212K SF office · 12 floors · built 1898
  5. 18 West Houston StreetOffice building with commercial space · 150K SF office · 9 floors · built 1894
All 9 buildings in NoHo

Tribeca

  1. 388 Greenwich StreetOffice building · 2.4M SF office · 39 floors · built 1989
  2. 38 Lafayette StreetOffice and commercial building · 1.7M SF office · 45 floors · built 1968
  3. 1 Centre StreetOffice building · 1.1M SF office · 39 floors · built 1914
  4. 290 BroadwayOffice building · 1.0M SF office · 32 floors · built 1994
  5. 306 BroadwayOffice building · 906K SF office · 41 floors · built 1977
All 21 buildings in Tribeca

Financial District

  1. 185 Greenwich StreetOffice building · 7.2M SF office · 104 floors · built 2009
  2. 43 Water StreetOffice condominium · 3.6M SF office · 53 floors · built 1973
  3. 200 West StreetOffice building · 2.2M SF office · 45 floors · built 2009
  4. 200 Vesey StreetOffice building · 2.1M SF office · 54 floors · built 1986
  5. 225 Liberty StreetOffice building · 2.0M SF office · 44 floors · built 1987
All 99 buildings in Financial District

Murray Hill

  1. 622 Third AvenueOffice building · 960K SF office · 41 floors · built 1974
  2. 605 Third AvenueOffice building · 887K SF office · 43 floors · built 1963
  3. 220 East 42nd StreetCommercial condominium · 820K SF office · 37 floors · built 1928
  4. 633 Third AvenueCommercial condominium · 699K SF office · 41 floors · built 1960
  5. 3 Park AvenueCommercial condominium · 592K SF office · 42 floors · built 1977
All 22 buildings in Murray Hill

Harlem

  1. 721 Esplanade Gardens PlazaOffice and commercial building · 294K SF office · 3 floors · built 2011
  2. 280 Street Nicholas AvenueShopping center · 248K SF retail · 4 floors · built 1998
  3. 450 West 126th StreetOffice building with commercial space · 235K SF office · 11 floors · built 2019
  4. 125 West 125th StreetOffice building with commercial space · 231K SF office · 19 floors · built 1972
  5. 55 West 125th StreetOffice building with commercial space · 181K SF office · 15 floors · built 1974
All 16 buildings in Harlem

Upper West Side

  1. 959 Eighth AvenueOffice condominium · 704K SF office · 42 floors · built 1928
  2. 555 West 57th StreetCommercial condominium · 581K SF office · 20 floors · built 2005
  3. 320 West 66th StreetOffice condominium · 474K SF office · 7 floors · built 1989
  4. 241 West 57th StreetCommercial condominium · 459K SF office · 25 floors · built 1927
  5. 250 West 57th StreetOffice building · 393K SF office · 26 floors · built 1921
All 15 buildings in Upper West Side

Williamsburg

  1. 292 Kent AvenueOffice condominium · 400K SF office · 14 floors · built 1885
  2. 185 Wythe AvenueWarehouse · 160K SF industrial and storage · 4 floors · built 1946
  3. 390 Kent AvenueWarehouse · 107K SF industrial and storage · 2 floors · built 1953
  4. 67 Kent AvenueFactory and industrial building · 106K SF industrial and storage · 2 floors · built 1932
  5. 16 North 11th StreetWarehouse · 97K SF industrial and storage · 1 floor · built 1999
All 9 buildings in Williamsburg

Greenpoint

  1. 1155 Manhattan AvenueFactory and industrial building · 361K SF industrial and storage · 6 floors · built 1906
  2. 19 Kent AvenueOffice building with commercial space · 272K SF office · 10 floors · built 2017
  3. 236 Greenpoint AvenueFactory and industrial building · 204K SF industrial and storage · 6 floors · built 1931
  4. 9 Kent AvenueFactory and industrial building · 111K SF industrial and storage · 2 floors · built 1965
  5. 425 Greenpoint AvenueSelf-storage building · 100K SF industrial and storage · 5 floors · built 1931
All 16 buildings in Greenpoint

Bushwick

  1. 513 Irving AvenueWarehouse · 58K SF industrial and storage · 1 floor · built 1960
Buildings in Bushwick

Dumbo

  1. 20 Jay StreetOffice building with commercial space · 418K SF office · 11 floors · built 1909
  2. 55 Water StreetOffice building with commercial space · 326K SF office · 5 floors · built 1900
  3. 45 Main StreetOffice building with commercial space · 275K SF office · 12 floors · built 1906
  4. 55 Prospect StreetOffice building with commercial space · 237K SF office · 10 floors · built 1967
  5. 77 Sands StreetOffice building with commercial space · 207K SF office · 12 floors · built 1962
All 16 buildings in Dumbo

Downtown Brooklyn

  1. 4 Metrotech CenterOffice building · 1.2M SF office · 24 floors · built 1990
  2. 330 Jay StreetOffice condominium · 978K SF office · 32 floors · built 2002
  3. 351 Jay StreetOffice building · 857K SF office · 23 floors · built 1990
  4. 350 Jay StreetCommercial condominium · 815K SF office · 32 floors · built 1997
  5. 115 Myrtle AvenueOffice building with commercial space · 622K SF office · 19 floors · built 2002
All 58 buildings in Downtown Brooklyn

Sunset Park

  1. 607 2nd AvenueWarehouse · 690K SF industrial and storage · 6 floors · built 1910
  2. 850 3rd AvenueWarehouse · 587K SF industrial and storage · 8 floors · built 1920
  3. 4312 2nd AvenueWarehouse · 581K SF industrial and storage · 6 floors · built 1917
  4. 88 33rd StreetOffice condominium · 567K SF office · 6 floors · built 1907
  5. 4000 1st AvenueWarehouse · 374K SF industrial and storage · 8 floors · built 1926
All 15 buildings in Sunset Park

Long Island City

  1. 25-01 Jackson AvenueOffice building · 1.3M SF office · 49 floors · built 1987
  2. 28-10 Queens Plaza SouthOffice building · 1.0M SF office · 27 floors · built 2017
  3. 47-07 30th PlaceOffice building with commercial space · 1.0M SF office · 10 floors · built 1920
  4. 24-02 49th AvenueOffice condominium · 655K SF office · 7 floors · built 1928
  5. 28-90 Review AvenueFactory and industrial building · 655K SF industrial and storage · 6 floors · built 2024
All 86 buildings in Long Island City

Astoria

  1. 34-37 37th StreetSelf-storage building · 128K SF industrial and storage · 7 floors · built 1926
  2. 36-06 34th AvenueOffice building with commercial space · 88K SF office · 4 floors · built 2018
  3. 30-14 Crescent StreetOffice condominium · 80K SF office · 7 floors · built 2021
  4. 31-21 Newtown AvenueOffice building with commercial space · 67K SF office · 10 floors · built 2011
  5. 12-01 34th AvenueWarehouse · 63K SF industrial and storage · 1 floor · built 1931
Buildings in Astoria

South Bronx

  1. 2 St. Ann's AvenueWarehouse · 566K SF industrial and storage · 2 floors · built 2017
  2. 825 East 141st StreetOffice building with commercial space · 241K SF office · 7 floors · built 1916
  3. 340 Bruckner BoulevardSelf-storage building · 223K SF industrial and storage · 8 floors · built 1929
  4. 200 East 135th StreetSelf-storage building · 212K SF industrial and storage · 4 floors · built 2000
  5. 430 Southern BoulevardFactory and industrial building · 186K SF industrial and storage · 5 floors · built 1931
All 35 buildings in South Bronx

Source: NYC Department of City Planning, PLUTO 26v2, pulled 2026-09-26. Floor areas are the city's estimates for whole buildings, not available space.