Medical office space for lease in the Upper East Side
The Upper East Side is one of Manhattan's main medical office markets, with practices clustered near NewYork-Presbyterian/Weill Cornell, Hospital for Special Surgery, Memorial Sloan Kettering and Lenox Hill Hospital. Madison Avenue carries luxury boutiques through the 60s and 70s, while Lexington, Third and Second Avenues and 86th Street hold neighborhood retail and restaurants.
- Office stock
- 8.6M SF
- Office properties
- 835
- Largest office
- 413 East 69th Street
- Transit
- 4 5 6 at 86 St
Building figures are existing stock from NYC PLUTO 26v2 tax lot records, not space on the market. More below.
On Leasemark No medical office space for lease and no requirements posted in the Upper East Side yet. Post yours and it is matched the day it goes up.
1 real space nearby: office space for lease at 783 Madison 4th Floor in the Upper East Side (994 SF, $66.40/SF/yr).
Nothing listed here yet
New medical spaces in the Upper East Side are matched to requirements the day they are posted. Post yours and be first in line.
Real space nearby
Listed now by its owner or broker, close to what this page covers. Open it and tap I'm interested to ask the lister for an intro; contact details are shared once both sides accept.
Listed as office space, not as medical space
783 Madison 4th Floor
For owners and brokers
Hear the moment a tenant looks for medical office space in the Upper East Side
Tenant alerts send a notification when a requirement that fits your neighborhood, types and sizes is posted, before you list anything. Real requirements only. Free during Broker Pro early access.
NYC tax lot records
Office buildings in the Upper East Side
What already stands here, from the city's own property data. Useful for sizing a search before a single space is listed.
- Office space
- 8.6M SF
- Properties with office space
- 835
- All commercial space
- 38.7M SF
- Built before 1940
- 76%
Largest office buildings
All 27 large commercial buildings in the Upper East SideAge, height and zoning
- Median year built: 1918.
- Median height: 5 floors.
- Most common zoning districts: R8B (813), C1-9 (412), R10 (411).
- Historic districts: Upper East Side Historic District (401 lots), Expanded Carnegie Hill Historic District (95 lots), Metropolitan Museum Historic District (58 lots).
- 69 lots are designated city landmarks.
Source: NYC Department of City Planning, PLUTO 26v2, pulled 2026-10-16. Counts cover tax lots with commercial floor area within about 0.6 mi of the Upper East Side's commercial core, and each lot counts toward one neighborhood only, so boundaries are approximate. Building figures are the city's floor-area estimates, not available space.
MTA station data
Subway stations in the Upper East Side
Every station within about 0.6 mi of the Upper East Side's commercial core, closest first. Stations joined by a free transfer count once.
- Stations
- 10
- Subway lines
- 8
- Fully accessible
- 5 of 10
- Closest
- 77 St, 1 min walk
The 10 stations
- 77 St
- 86 St
- 68 St-Hunter College
- 86 St
- Lexington Av/63 St
- 72 St
- Lexington Av/59 St
- 96 St
- 96 St
- 5 Av/59 St
Lines
The 4, 5, 6, M, N, Q, R and W trains stop within about 0.6 mi of the Upper East Side's core.
Step-free access
- 68 St-Hunter College (6) is fully accessible.
- 86 St (Q) is fully accessible.
- Lexington Av/63 St (M Q) is fully accessible.
- 72 St (Q) is fully accessible.
- 96 St (Q) is fully accessible.
- 86 St (4 5 6) is partly accessible (one direction only).
Source: Metropolitan Transportation Authority, MTA Subway Stations, pulled 2026-10-16. Walking times are straight-line estimates from the nearest point of the Upper East Side's commercial core (the same area as the building counts), so the street route is longer. Accessibility is the MTA's rating for the named station. PATH, LIRR, Metro-North and ferries are not in this data.
Before you sign
Plain-English guides to square footage, rent and lease terms in New York, and free calculators to run your own numbers.
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Rentable vs usable square feet and the loss factor, explained
Rentable vs usable square feet in NYC: what the loss factor is, how to calculate it, and why two 5,000 SF suites at the same rent can be very different deals.
What does $/SF/yr mean? How to calculate rent per square foot
$/SF/yr is a year's rent for one square foot. How to turn it into a monthly bill, spot a monthly quote, and see what the rate leaves out before you compare spaces.
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Office space calculator
How many square feet your team needs, from headcount and layout to a rentable range.
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Commercial rent calculator
Turn a price per square foot into monthly and yearly rent, with increases, free rent and net effective rent.
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TI allowance calculator
A landlord's build-out allowance in dollars, what it covers of your budget and what the rest adds to the rent.
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Commercial Rent Tax calculator
Whether a Manhattan lease owes the city's Commercial Rent Tax, and roughly how much a year.
Questions about medical space in the Upper East Side
Is there medical space for lease in the Upper East Side right now?
No medical space for lease in the Upper East Side is listed on Leasemark right now. Nearby on Leasemark: office space for lease at 783 Madison 4th Floor in the Upper East Side (994 SF, $66.40/SF/yr). Post what you need and Leasemark matches you the day a space that fits is listed; your contact details stay private until you accept an intro. Owners and brokers can list a space here for free.
How much does medical space cost in the Upper East Side?
Pricing depends on building class, floor, condition and lease length. Post a requirement with your budget and Leasemark will match you with spaces that fit it as they are listed.
How do I find medical space in the Upper East Side that is not publicly listed?
Post a requirement on Leasemark. Owners and listing brokers see what you need (without your contact details) and can respond with spaces, including ones that are not on the market yet. You choose who gets an intro.
How much office space is there in the Upper East Side?
New York City's PLUTO tax lot data (26v2) records about 8.6 million square feet of office floor area across 835 properties in the part of the Upper East Side Leasemark covers. The largest by that measure is 413 East 69th Street, at about 243,000 square feet. That is the existing building stock, not space currently for lease.
What subway lines serve the Upper East Side?
Ten subway stations sit within about 0.6 mi of the Upper East Side's commercial core, served by the 4, 5, 6, M, N, Q, R and W trains. The closest is 77 St (6), roughly 1 minute on foot; then 86 St (4 5 6), 68 St-Hunter College (6), 86 St (Q), Lexington Av/63 St (M Q), 72 St (Q), Lexington Av/59 St (N R W 4 5 6) and 3 more. Walking times are straight-line estimates from MTA station data.
Do tenants in the Upper East Side pay the NYC Commercial Rent Tax?
It depends on the address. The tax covers Manhattan premises south of the center line of 96th Street, and the Upper East Side runs up to that line: space below 96th Street is in the zone, space above it is not. A tenant owes it only when base rent for the space is $250,000 a year or more. The tax is 6% of base rent after a 35% reduction, so 3.9% of rent, with a sliding credit between $250,000 and $300,000, and the Small Business Tax Credit wipes it out for businesses with total income of $5 million or less and base rent under $500,000.
Is it free to post on Leasemark?
Yes. Posting a space or a requirement is free. Contact details are only shared when both sides accept an intro.