Medical office space for lease in Midtown
Midtown is the largest office market in the country, anchored by the Plaza District, Sixth Avenue, and the Rockefeller Center corridor. Inventory runs from trophy towers to smaller prewar buildings on the side streets, which is where most full-floor deals under 10,000 SF happen.
- Office stock
- 137M SF
- Office properties
- 774
- Largest office
- 1221 Avenue of the Americas
- Transit
- B D F M at 42 St-Bryant Pk
Building figures are existing stock from NYC PLUTO 26v2 tax lot records, not space on the market. More below.
On Leasemark No medical office space for lease and no requirements posted in Midtown yet. Post yours and it is matched the day it goes up.
1 real space nearby: office space for lease at 783 Madison 4th Floor in the Upper East Side (994 SF, $66.40/SF/yr).
Nothing listed here yet
New medical spaces in Midtown are matched to requirements the day they are posted. Post yours and be first in line.
Real space nearby
Listed now by its owner or broker, close to what this page covers. Open it and tap I'm interested to ask the lister for an intro; contact details are shared once both sides accept.
Listed as office space, next door in the Upper East Side
783 Madison 4th Floor
For owners and brokers
Hear the moment a tenant looks for medical office space in Midtown
Tenant alerts send a notification when a requirement that fits your neighborhood, types and sizes is posted, before you list anything. Real requirements only. Free during Broker Pro early access.
NYC tax lot records
Office buildings in Midtown
What already stands here, from the city's own property data. Useful for sizing a search before a single space is listed.
- Office space
- 137M SF
- Properties with office space
- 774
- All commercial space
- 164M SF
- Built before 1940
- 66%
Largest office buildings
All 357 large commercial buildings in MidtownAge, height and zoning
- Median year built: 1926.
- Median height: 7 floors.
- Most common zoning districts: C5-3 (278), R8B (170), C1-9 (139).
- Historic districts: Upper East Side Historic District (49 lots), Turtle Bay Gardens Historic District (2 lots), Scenic Landmark (1 lot).
- 119 lots are designated city landmarks.
Source: NYC Department of City Planning, PLUTO 26v2, pulled 2026-10-16. Counts cover tax lots with commercial floor area within about 0.4 mi of Midtown's commercial core, and each lot counts toward one neighborhood only, so boundaries are approximate. Building figures are the city's floor-area estimates, not available space.
MTA station data
Subway stations in Midtown
Every station within about 0.5 mi of Midtown's commercial core, closest first. Stations joined by a free transfer count once.
- Stations
- 18
- Subway lines
- 19
- Fully accessible
- 10 of 18
- Closest
- 47-50 Sts-Rockefeller Ctr, 1 min walk
The 18 stations
- 47-50 Sts-Rockefeller Ctr
- 42 St-Bryant Pk
- 49 St
- Times Sq-42 St
- 7 Av
- 5 Av/59 St
- 50 St
- 51 St
- 5 Av/53 St
- 57 St
- 59 St
- 57 St-7 Av
- Grand Central-42 St
- 50 St
- Lexington Av/63 St
- 34 St-Herald Sq
- 34 St-Penn Station
- 59 St-Columbus Circle
Lines
The 1, 2, 3, 4, 5, 6, 7, A, B, C, D, E, F, M, N, Q, R, W and S trains stop within about 0.5 mi of Midtown's core.
Step-free access
- 47-50 Sts-Rockefeller Ctr (B D F M) is fully accessible.
- Times Sq-42 St (1 2 3 7 N Q R W S) is fully accessible.
- 51 St (6) is fully accessible.
- 57 St (M) is fully accessible.
- 57 St-7 Av (N Q R W) is fully accessible.
- Grand Central-42 St (4 5 6 7 S) is fully accessible.
- Lexington Av/63 St (M Q) is fully accessible.
- 34 St-Herald Sq (B D F M N Q R W) is fully accessible.
- 34 St-Penn Station (1 2 3) is fully accessible.
- 59 St-Columbus Circle (1 A B C D) is fully accessible.
- 49 St (N R W) and 50 St (C E) are partly accessible (one direction only).
Source: Metropolitan Transportation Authority, MTA Subway Stations, pulled 2026-10-16. Walking times are straight-line estimates from the nearest point of Midtown's commercial core (the same area as the building counts), so the street route is longer. Accessibility is the MTA's rating for the named station. PATH, LIRR, Metro-North and ferries are not in this data.
Before you sign
Plain-English guides to square footage, rent and lease terms in New York, and free calculators to run your own numbers.
Good guy guarantee in NYC commercial leases
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Rentable vs usable square feet and the loss factor, explained
Rentable vs usable square feet in NYC: what the loss factor is, how to calculate it, and why two 5,000 SF suites at the same rent can be very different deals.
What does $/SF/yr mean? How to calculate rent per square foot
$/SF/yr is a year's rent for one square foot. How to turn it into a monthly bill, spot a monthly quote, and see what the rate leaves out before you compare spaces.
- Free calculator
Office space calculator
How many square feet your team needs, from headcount and layout to a rentable range.
- Free calculator
Commercial rent calculator
Turn a price per square foot into monthly and yearly rent, with increases, free rent and net effective rent.
- Free calculator
TI allowance calculator
A landlord's build-out allowance in dollars, what it covers of your budget and what the rest adds to the rent.
- Free calculator
Commercial Rent Tax calculator
Whether a Manhattan lease owes the city's Commercial Rent Tax, and roughly how much a year.
Questions about medical space in Midtown
Is there medical space for lease in Midtown right now?
No medical space for lease in Midtown is listed on Leasemark right now. Nearby on Leasemark: office space for lease at 783 Madison 4th Floor in the Upper East Side (994 SF, $66.40/SF/yr). Post what you need and Leasemark matches you the day a space that fits is listed; your contact details stay private until you accept an intro. Owners and brokers can list a space here for free.
How much does medical space cost in Midtown?
Pricing depends on building class, floor, condition and lease length. Post a requirement with your budget and Leasemark will match you with spaces that fit it as they are listed.
How do I find medical space in Midtown that is not publicly listed?
Post a requirement on Leasemark. Owners and listing brokers see what you need (without your contact details) and can respond with spaces, including ones that are not on the market yet. You choose who gets an intro.
How much office space is there in Midtown?
New York City's PLUTO tax lot data (26v2) records about 137.2 million square feet of office floor area across 774 properties in the part of Midtown Leasemark covers. The largest by that measure is 1221 Avenue of the Americas, at about 2.4 million square feet. That is the existing building stock, not space currently for lease.
What subway lines serve Midtown?
18 subway stations sit within about 0.5 mi of Midtown's commercial core, served by the 1, 2, 3, 4, 5, 6, 7, A, B, C, D, E, F, M, N, Q, R, W and S trains. The closest is 47-50 Sts-Rockefeller Ctr (B D F M), roughly 1 minute on foot; then 42 St-Bryant Pk (B D F M 7), 49 St (N R W), Times Sq-42 St (1 2 3 7 N Q R W S A C E), 7 Av (B D E), 5 Av/59 St (N R W), 50 St (1) and 11 more. Walking times are straight-line estimates from MTA station data.
Do tenants in Midtown pay the NYC Commercial Rent Tax?
Yes, for larger leases. Midtown is in Manhattan below 96th Street, where the city's Commercial Rent Tax applies. A tenant owes it only when base rent for the space is $250,000 a year or more. The tax is 6% of base rent after a 35% reduction, so 3.9% of rent, with a sliding credit between $250,000 and $300,000, and the Small Business Tax Credit wipes it out for businesses with total income of $5 million or less and base rent under $500,000.
Is it free to post on Leasemark?
Yes. Posting a space or a requirement is free. Contact details are only shared when both sides accept an intro.