Medical office space for lease in Harlem
Harlem's 125th Street corridor is a major retail spine with national tenants, and the neighborhood has seen new office and lab development around Columbia's Manhattanville campus.
- Office stock
- 7.7M SF
- Office properties
- 311
- Largest office
- 721 Esplanade Gardens Plaza
- Transit
- 2 3 at 125 St
Building figures are existing stock from NYC PLUTO 26v2 tax lot records, not space on the market. More below.
On Leasemark No medical office space for lease and no requirements posted in Harlem yet. Post yours and it is matched the day it goes up.
1 real space nearby: office space for lease at 783 Madison 4th Floor in the Upper East Side (994 SF, $66.40/SF/yr).
Nothing listed here yet
New medical spaces in Harlem are matched to requirements the day they are posted. Post yours and be first in line.
Real space nearby
Listed now by its owner or broker, close to what this page covers. Open it and tap I'm interested to ask the lister for an intro; contact details are shared once both sides accept.
Listed as office space, next door in the Upper East Side
783 Madison 4th Floor
For owners and brokers
Hear the moment a tenant looks for medical office space in Harlem
Tenant alerts send a notification when a requirement that fits your neighborhood, types and sizes is posted, before you list anything. Real requirements only. Free during Broker Pro early access.
NYC tax lot records
Office buildings in Harlem
What already stands here, from the city's own property data. Useful for sizing a search before a single space is listed.
- Office space
- 7.7M SF
- Properties with office space
- 311
- All commercial space
- 30.9M SF
- Built before 1940
- 77%
Largest office buildings
All 34 large commercial buildings in HarlemAge, height and zoning
- Median year built: 1910.
- Median height: 5 floors.
- Most common zoning districts: R7-2 (937), R7A (310), R8 (143).
- Historic districts: Mount Morris Park Historic District (47 lots), Hamilton Heights Historic District Extension (26 lots), Hamilton Heights / Sugar Hill Historic District (26 lots).
- 49 lots are designated city landmarks.
Source: NYC Department of City Planning, PLUTO 26v2, pulled 2026-10-16. Counts cover tax lots with commercial floor area within about 0.6 mi of Harlem's commercial core, and each lot counts toward one neighborhood only, so boundaries are approximate. Building figures are the city's floor-area estimates, not available space.
MTA station data
Subway stations in Harlem
Every station within about 0.6 mi of Harlem's commercial core, closest first. Stations joined by a free transfer count once.
- Stations
- 17
- Subway lines
- 10
- Fully accessible
- 5 of 17
- Closest
- 145 St, 3 min walk
The 17 stations
- 145 St
- 116 St
- 125 St
- 125 St
- 116 St
- 135 St
- Harlem-148 St
- 135 St
- 145 St
- 110 St-Malcolm X Plaza
- 145 St
- 137 St-City College
- 116 St
- 155 St
- 125 St
- Cathedral Pkwy (110 St)
- 155 St
Lines
The 1, 2, 3, 4, 5, 6, A, B, C and D trains stop within about 0.6 mi of Harlem's core.
Step-free access
- 125 St (A B C D) is fully accessible.
- 135 St (2 3) is fully accessible.
- Harlem-148 St (3) is fully accessible.
- 137 St-City College (1) is fully accessible.
- 125 St (4 5 6) is fully accessible.
Source: Metropolitan Transportation Authority, MTA Subway Stations, pulled 2026-10-16. Walking times are straight-line estimates from the nearest point of Harlem's commercial core (the same area as the building counts), so the street route is longer. Accessibility is the MTA's rating for the named station. PATH, LIRR, Metro-North and ferries are not in this data.
Before you sign
Plain-English guides to square footage, rent and lease terms in New York, and free calculators to run your own numbers.
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Rentable vs usable square feet and the loss factor, explained
Rentable vs usable square feet in NYC: what the loss factor is, how to calculate it, and why two 5,000 SF suites at the same rent can be very different deals.
What does $/SF/yr mean? How to calculate rent per square foot
$/SF/yr is a year's rent for one square foot. How to turn it into a monthly bill, spot a monthly quote, and see what the rate leaves out before you compare spaces.
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Office space calculator
How many square feet your team needs, from headcount and layout to a rentable range.
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Commercial rent calculator
Turn a price per square foot into monthly and yearly rent, with increases, free rent and net effective rent.
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TI allowance calculator
A landlord's build-out allowance in dollars, what it covers of your budget and what the rest adds to the rent.
Questions about medical space in Harlem
Is there medical space for lease in Harlem right now?
No medical space for lease in Harlem is listed on Leasemark right now. Nearby on Leasemark: office space for lease at 783 Madison 4th Floor in the Upper East Side (994 SF, $66.40/SF/yr). Post what you need and Leasemark matches you the day a space that fits is listed; your contact details stay private until you accept an intro. Owners and brokers can list a space here for free.
How much does medical space cost in Harlem?
Pricing depends on building class, floor, condition and lease length. Post a requirement with your budget and Leasemark will match you with spaces that fit it as they are listed.
How do I find medical space in Harlem that is not publicly listed?
Post a requirement on Leasemark. Owners and listing brokers see what you need (without your contact details) and can respond with spaces, including ones that are not on the market yet. You choose who gets an intro.
How much office space is there in Harlem?
New York City's PLUTO tax lot data (26v2) records about 7.7 million square feet of office floor area across 311 properties in the part of Harlem Leasemark covers. The largest by that measure is 721 Esplanade Gardens Plaza, at about 294,000 square feet. That is the existing building stock, not space currently for lease.
What subway lines serve Harlem?
17 subway stations sit within about 0.6 mi of Harlem's commercial core, served by the 1, 2, 3, 4, 5, 6, A, B, C and D trains. The closest is 145 St (A B C D), roughly 3 minutes on foot; then 116 St (2 3), 125 St (2 3), 125 St (A B C D), 116 St (B C), 135 St (2 3), Harlem-148 St (3) and 10 more. Walking times are straight-line estimates from MTA station data.
Do tenants in Harlem pay the NYC Commercial Rent Tax?
No. Harlem is north of 96th Street, and the city repealed the Commercial Rent Tax for premises north of the center line of 96th Street, so a commercial lease here does not pay it at any rent. Space south of 96th Street does.
Is it free to post on Leasemark?
Yes. Posting a space or a requirement is free. Contact details are only shared when both sides accept an intro.